Our previous study of HGPS disease revealed the crucial role of elevated Sun2 expression in response to cytoskeleton stiffness, nuclear blebbing, micronuclei formation, and changes in RhoA/ROCK activity in progeria cells [41], however, it was unclear whether Sun2 plays a role in mediating mechanical stress-induced nuclear damage, and whether suppression of Sun2 expression may help preventing mechanical stress-induced nuclear damage. Here, SUN2 is linked to Hutchinson-Gilford progeria syndrome.