TNF and diabetes mellitus: In the literature, expression of SCUBE-1 was shown in especially vascular endothelial cells of highly vascular tissues,8 and SCUBE-1 levels were found to increase in conditions such as acute coronary syndrome, acute ischemic stroke, DM, malignities, and also psoriasis.9, 10, 11, 29, 30 Furthermore, the SCUBE-1 levels were decreased by treatments against IL-1β and TNF-α.8