However, interferon-gamma release assays (IGRAs) and tuberculin skin tests are screening tests approved by the WHO.9 IGRAs are advantageous since prior BCG vaccination does not affect their performance characteristics.23 HIV impacts the QuantiFERON-TB Gold In-Tube test (QFT-GIT) less than it does the ELISPOT (T SPOT-TB).24 25 The QFT Gold Plus (QFT-Plus) and its forerunner, the QFT-GIT, have concordant performance.26 27 This paper presents the results of a study that sought to estimate TB infection prevalence among PLHIV using the QFT-Plus assay in a high TB burden context. Here, IFNG is linked to tuberculosis.