IFNG and neoplasm: To increase the effectiveness of both NK cells and anti-PD-1 therapy we sequentially we sequentially treated the tumor bearing hu-BLT mice with sNK cells and anti-PD-1 therapy and found such treatment to not only prevent and remove most of tumors from the mice but also it augmented the function of immune cells by increasing the secretion of IFN-γ when both treatments were used in mice.