On the other hand, if the tumor phenotype is tilted towards a well-differentiated phenotype, this may increase effectiveness of NK cells in mediating ADCC since tumor cells will be upregulating PD-L1 and becoming susceptible to NK cell-mediated ADCC effect, whereas such tumors are not, or are less susceptible to direct cytotoxicity by the primary NK cells as seen in our studies (Figure 5). This evidence concerns the gene CD274 and neoplasm.