The in-vivo studies revealed how the combination of sNK cells with chemotherapy or sNK cells with anti-PD1 antibody reduce tumor burden and either restore or increase IFN-γ secretion, and cytotoxic function of NK cells in various tissue compartments of oral and pancreatic tumor-bearing humanized-BLT (hu-BLT) mice. Here, IFNG is linked to neoplasm.