IRF3 and infection: Following infection of 229E or OC43, most antiviral genes we examined (except GBP2 in IRF7-transfected cells infected with 229E and IFIT2 in IRF1-transfected cells infected with OC43) were significantly elevated in cells introduced with IRF1, IRF3 or IRF7 compared to the vector control infected cells (Figures 6B, C).