While GBP2 induction in MRC5 cells infected with 229E or OC43 infection was lower than those stimulated with IFN-γ, the expression levels of RIG-I and STAT2 induced by 229E or OC43 infection were similar to those induced by IFN-α or -γ stimulation (Supplementary Figure 2). Here, GBP2 is linked to infection.