Then, the expression of the following IFN-inducible genes was examined during 229E (Figure 2C) or OC43 (Figure 2D) infection: guanylate binding protein 2 (GBP2) (57), interferon induced protein 44 (IFI44) (58), interferon induced protein with tetratricopeptide repeats 2 (IFIT2) (59), microtubule-associated protein 2 (MAP2) (54), retinoic acid-inducible gene I (RIG-I) (60) and STAT2 (61). This evidence concerns the gene RIGI and infection.