Following infection of 229E or OC43, most antiviral genes we examined (except GBP2 in IRF7-transfected cells infected with 229E and IFIT2 in IRF1-transfected cells infected with OC43) were significantly elevated in cells introduced with IRF1, IRF3 or IRF7 compared to the vector control infected cells (Figures 6B, C). The gene discussed is GBP2; the disease is infection.