Subsequently, to further determine the clinical value of these DEPs, we combined 62 human homologous proteins originating from 60 common DEPs of mice with proteomic data from lung tissue and plasma of COVID-19-related ARDS cases and ascertained six proteins of human orthologs (HP, LTA4H, S100A9, SAA1, SAA2, and SERPINA3) with good clinical diagnostic and prognostic value. Here, SERPINA3 is linked to COVID-19.