RUNX2 and osteosarcoma: On the other hand, nuclear translocated β-catenin acts as a transcriptional coactivator for the TCF/LEF family of transcription factors promoting the expression of Wnt-target genes such as C-myc, RUNX2, and CyclinD1, which subsequently promotes the epithelial–mesenchymal transition and facilitates osteosarcoma metastasis (40, 41).