GAA and neoplasm: The GSVA results revealed that a serial of immune-associated pathways was up-regulated in cluster C. Moreover, immune infiltration results also showed better immunotherapy response, higher immunoreactivity and lower immunosuppression in cluster C. Aggregating all of these findings, we hypothesized that GC patients in different LYAG subtypes would have different prognosis due to different immune response and immune status tumor microenvironment, and these differences contribute to tumor progression.