According to previous research, 21 genes highly related to NSCLC cell proliferation and OS of patients with NSCLC in the study were added, including 11 potential tumor suppressor genes (AFF3, AhR, AR, CBFA2T3, CHD4, KANK2, NR3C2, PTEN, PRDM16, RB1, and STK11) and 10 potential oncogenes (BARX1, DLX6, ELF3, EN1, ETV1, FOXBE1, IRX4, IRX5, and SALL1) (30). The gene discussed is IRX5; the disease is non-small cell lung carcinoma.