TGFB1 and neoplasm: Moreover, KEGG pathway enrichment analysis showed that 725 genes were involved in many pathways, including tumor transcriptional regulation interrelated to oncogenesis and development, the Hippo signaling pathway, TGF-β signaling pathway, cell cycle, immune-related Th17 cell differentiation, and Th1 and Th2 cell differentiation (Figure 2D).