First, to further explore the function of SETDB2, SNAI3, SCML4, ZNF540, and ETV1 in lung cancer cell lines, the mRNA expression levels in the normal human bronchial epithelial cell line (BEAS-2B), lung adenocarcinoma cell lines (A549, HCC827, H1299, and H1975), and lung squamous cell lines (EPLC-272H, H226, H157, and H2170) were measured (Figure 8A). The gene discussed is SETDB2; the disease is lung cancer.