Similarly, extracellular AGR2 can also directly promote the dimerization of VEGF and FGF2 and increase the concentration of active VEGF and FGF2 in the local environment of tumor, thus leading to the migration and aggregation of vascular endothelial cells and fibroblasts to the surrounding of tumor cells, and promoting angiogenesis, providing favorable conditions for the formation of tumor microenvironment (41). Here, FGF2 is linked to neoplasm.