Univariate and multivariate analysis showed that tumor size ≥5 cm (P < 0.001), ALB <35 g/L (P < 0.001), PIVKAII ≥20 mAU/mL (P = 0.001), cirrhosis (P < 0.001), and tumor RECIST response (P < 0.001) were independent risk factors of OS (Table 3). Here, ALB is linked to Cirrhosis.