CD4 and neoplasm: Most cancer immune cycles were more active in patients with high a VM_Score; for example, the release of cancer cell antigens (step 1), trafficking of immune cells to the tumor (step 4) (recruitment of CD8 T cells, CD4 T cells, macrophages, Th1 cells, NK cells, and DCs), and killing of cancer cells (Step 7) (Figure 5A).