Functionally, miR-765 abolishes the inhibitory effect of Mhrt on ANP, BNP, and β-MHC levels and induces enlargement of the cardiomyocyte surface area, suggesting that Mhrt attenuated Ang II-induced cardiac hypertrophy by sponging miR-765 in this study. The gene discussed is NPPA; the disease is cardiac hypertrophy.