The apoptosis-associated speck-like protein (ASC) with a recruitment domain and effector proteins caspase-1 (casp1), IL-1β, and IL-18 is vital in various inflammatory immune diseases, including type 2 diabetes, through cascading activation of the NLRP3-ASC-casp1-IL-1β/IL-18 axis upon corresponding stimulation [22,23]. This evidence concerns the gene IL1B and type 2 diabetes mellitus.