Recent studies found that Fn regulates M1 macrophage polarization, promotes expression of inflammatory cytokines, and induces autophagy disorder, oxidative stress damage, and epithelial cell death, thus leading to intestinal epithelial barrier damage and aggravating colitis (Liu et al., 2019; Chen et al., 2020; Duan et al., 2021; Liu et al., 2021). Here, FN1 is linked to colitis.