This condition warrants emergency intervention as it can lead to life-threatening obstruction of airways [2,3,13,14]. The preferred management for ACEi-induced angioedema depends on the clinical picture, as there are no laboratory studies available currently to establish this particular etiology and diagnosis compared to hereditary angioedema, which is diagnosed with low levels of C2, C4, and C1 esterase inhibitors [4]. Here, C4A is linked to hereditary angioedema.