Interestingly, a recent study investigating histotripsy’s impact on metastatic development in a rodent liver tumor model identified increased infiltration of CD11b positive cells, CD8 positive T-cells, and natural killer (NK) cells at the histotripsy ablation zone seven days following treatment when > 50% of the tumor was ablated, but not when < 25% of the tumor was targeted [35]. The gene discussed is ITGAM; the disease is neoplasm.