In addition, our sociodemographic analysis found that overweight and obese individuals with MDD had an earlier age of onset, a tendency that may be attributable to pro-inflammatory mediators such as C-reactive protein (CRP) and interleukin-6 (IL-6), which are synthesized in response to proliferating adipose tissue (Tilg and Moschen, 2006). Here, CRP is linked to major depressive disorder.