ACTA2 and cancer: Although the inflamed normal-derived fibroblasts prominently expressed ACTA2, PDGFRB, and CD146, which were hallmarks of FbS3 myofibroblasts and FbS4 pericytes in the scRNA-seq data analysis, the metaplasia-derived fibroblasts were enriched instead for genes up-regulated in FbS2, such as FBLN2 and CD248. Of note, the cancer-derived fibroblasts had significantly increased expression of PDGFRA and PDPN compared with inflamed normal-derived cells, indicating these fibroblasts were transcriptionally similar to FbS1 (Figure 3C).