First evidence for the involvement of IL4i1 in the suppression of anti-tumor immune responses derived from mouse melanoma models in which IL4i1 expression provoked decreased CD8+ T cell responses and modulated the composition of tumor infiltrating immune cells, promoting higher numbers of immunosuppressive cell populations such as MDSCs and FoxP3+ Tregs while limiting tumor infiltration with CD8+ T cells (45, 133). This evidence concerns the gene FOXP3 and neoplasm.