Alike known oncogenic fusion ITK (interleukin-2-induced T-cell kinase)-spleen tyrosine kinase in peripheral T-cell lymphomas, ITK–FER has also been identified as another potential oncogene in peripheral T-cell lymphomas by paired DNA and RNA next-generation sequencing analysis (Fig. 7A, ITK–FER fusion 1) (37). Here, SYK is linked to peripheral T-cell lymphoma, not otherwise specified.