For example, genetic variations at the PIK3CG loci have been associated with attention-deficit/hyperactivity disorder,68 CAMK1D loci in T2DM,69 NCAM1 loci in cardiovascular problem,70 NRXN3 loci in neurodevelopmental/neuropsychiatric disorders,71,72,73,74 cardiovascular disease,75,76,77,78 and variants at TGFBR3 loci are shown to be risk factors in schizophrenia, bipolar, and major depressive disorder,79 vasculature development, and cardiovascular health.80 This evidence concerns the gene NRXN3 and major depressive disorder.