PIK3CG and major depressive disorder: For example, genetic variations at the PIK3CG loci have been associated with attention-deficit/hyperactivity disorder,68 CAMK1D loci in T2DM,69 NCAM1 loci in cardiovascular problem,70 NRXN3 loci in neurodevelopmental/neuropsychiatric disorders,71,72,73,74 cardiovascular disease,75,76,77,78 and variants at TGFBR3 loci are shown to be risk factors in schizophrenia, bipolar, and major depressive disorder,79 vasculature development, and cardiovascular health.80