TLR7 and COVID-19: In addition to TLR7, for which association has consistently been reported across studies (70, 71, 74, 76, 78), two genes reached the less conservative exome-wide significance threshold of 2.5×10−6 in one study focusing on 5,085 individuals with critical COVID-19 and 571,737 controls, mostly uninfected, from the general population (70): MARK1 (P = 1.9×10−6) and RILPL1 (P = 2.4×10−6), with cases displaying an enrichment in pLOF variants.