TARDBP and Alzheimer disease: The atrophy in the temporal pole is consistent with the location of neuronal loss and neurofibrillary tangles in AD [41], the distribution of temporal lobe atrophy with advancing disease [42], and the progression of TDP-43 pathology in AD: stage 2 for atrophy in hippocampus and/or entorhinal cortex and stage 3 for extension to the anterior temporal pole cortex [43].