USP11 phosphorylates TβRΙ by deubiquitinating TβRII and reducing TβRII ubiquitination degradation, which then activates the downstream Smad2/3 or nonclassical pathway to promote the activation of downstream senescence signalling pathways and the development of renal fibrosis [145]. Here, TGFBR2 is linked to renal fibrosis.