In mouse models of pulmonary fibrosis and human lung fibroblasts, a reduction in SIRT3 promotes the acetylation (inactivation) of oxidative stress response regulators and FMD, while SIRT3 overexpression weakens TGFβ1-mediated FMD and significantly reduces the levels of SMAD3. Here, SIRT3 is linked to pulmonary fibrosis.