Similarly, in mice with streptozotocin (STZ, 60 mg/kg, ip)-induced diabetes mellitus, SIRT3 deletion resulted in the upregulation of inflammatory mediators such as NLRP3, caspase-1 p20, and IL-1 β, ultimately exacerbating diabetic cardiomyopathy [54]. This evidence concerns the gene NLRP3 and diabetic cardiomyopathy.