Acetylated LKB1 was significantly increased in Htt-expressing cells, while viniferin could induce SIRT3 to promote the deacetylation of LKB1, thereby increasing the level of phosphorylated AMPK (activated AMPK) and promoting mitochondrial homeostasis [158], suggesting that the SIRT3-LKB1-AMPK pathway plays a crucial role in HD. This evidence concerns the gene SIRT3 and Huntington disease.