SIRT3 and Huntington disease: Notably, Salamon and colleagues assessed the expression patterns of three SIRT3 mRNA isoforms (SIRT3-M1/2/3) in the striatum, cortex and cerebellum by using the N171-82Q transgenic mouse model of HD and found a significant increase in SIRT3-M3 in the striatum and cortex, while transgene in cerebellum led to increased expression of all evaluated subtypes and isoform [161].