The JAK-STAT signalling pathway might also mediate COVID-19-induced cytokine storms, leading to the upregulation of APOL1. This hypothesis was evaluated in an iPSC-derived kidney organoid cultured with COVID-19-induced cytokines, in which it was shown that SARS-CoV-2 ultimately caused organoid podocyte injury. Here, APOL1 is linked to COVID-19.