In WM we observed more global changes including decreased levels of ACAA1 (Kruskal-Wallis p=0.0001, post-hoc Dunn’s test ADI-II vs MA p=0.0009, ADIII-IV vs MA p=0.00001, and ADV-VI vs MA p=0.002) and EHHDAH (post-hoc Dunn’s test ADIII-IV vs MA p=0.03, and ADV-VI vs MA p=0.04), and increased levels of ACOX3 (Kruskal-Wallis p=0.03, post-hoc Dunn’s test ADI-II vs MA p=0.003, and ADV-VI vs MA p=0.01), reinforcing the idea that AD affects differently both brain matters. Here, ACAA1 is linked to Alzheimer disease.