Interestingly, AD progression was also associated with an increase in GM’s DBI (Spearman’s Rho=0.425, correlation p-value=0.048), together with changes in delta-6 desaturase (Spearman’s Rho=0.456, correlation p-value=0.032), elovl6 (Spearman’s Rho= -0.587, correlation p-value=0.004), elovl2-5(n-6 and n-3) (Spearman’s Rho= -0.426, correlation p-value=0.047 and Spearman’s Rho= -0.519, correlation p-value=0.013), respectively), elovl2 (Spearman’s Rho=0.537, correlation p-value=0.009) estimation activities, and peroxisomal β-oxidation (Spearman’s Rho=0.495, correlation p-value=0.019) (Table 3). Here, FADS2 is linked to Alzheimer disease.