Specifically, in GM we found decreased expression of two elongases (ELVOL4 (Kruskal-Wallis p=0.008, post-hoc Dunn’s test ADIII-IV vs MA p=0.04, ADV-VI vs MA p=0.006) and ELVOL6 (Kruskal-Wallis p=0.001, post-hoc Dunn’s test ADIII-IV vs MA p=0.005, ADV-VI vs MA p=0.08)) in middle-latter stages of AD and increased expression of the elongase ELVOL7 (Kruskal-Wallis p=0.02, post-hoc Dunn’s test ADIII-IV vs MA p=0.02) and the desaturase FADS1 (Kruskal-Wallis p=0.017). Here, FADS1 is linked to Alzheimer disease.