FFAR4 and osteoarthritis: Edible oils with a low omega-6/omega-3 PUFAs ratio can activate GPR120, thereby inhibiting the NF-κB pathway and its downstream matrix metalloproteinase 13 (MMP13) and aggrecan 5 (a disintegrin and metalloprotease with thrombospondin motifs 5, ADAMTS5) [65], protects cartilage cells and can effectively treat osteoarthritis [66].