Limited studies have focused on the role of FUT8 in the cardiovascular system, but only one study has demonstrated that FUT8 regulates the TGF-β/Smad2/3 signaling pathway in the aortic smooth muscle of a uremia rat model by influencing core fucosylation of TGF-βR II and ALK5, resulting in vascular calcification [74]. The gene discussed is SMAD2; the disease is uremia.