Cripto-1 or teratocarcinoma-derived growth factor-1 (TDGF-1) was found to have a significant association with tumor recurrence/metastasis in BCa patients (P = 0.007) and also as an independent prognostic factor identified with multivariate Cox regression analysis (P = 0.036), which validated its role to be a valuable marker as a disease-free predictor in BCa patients [14]. The gene discussed is CRIPTO; the disease is neoplasm.