This is particularly meaningful because a 10 year risk of Alzheimer’s Disease was found to be greater for APOE ε44 genotype carriers [109] which is more predictive of AD when associated with cerebrovascular disease, and for women, middle to late adulthood hypertension was associated with an increased risk of dementia [110, 111]. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.