The median baseline IL-6, IL-10 and CRP levels in the patients who developed Severe-IRIS-KS was significantly higher than in patients without Severe-IRIS-KS events: IL6 36 pg/ml, IQR 16.1–50 vs. 15.5 pg/ml, IQR 11.7–22 (p = 0.018) and IL10 76.8 pg/ml, IQR 21–1075 vs. 15.1 pg/ml, IQR 9.9–32, (p = 0.01), CRP 3.4, IQR 3.3–10.1, vs. 1.1, IQR 0.49–1.9, (p = 0.001). The gene discussed is IL6; the disease is Kaposi's sarcoma.