SLC5A2 and bacterial infectious disease: Although the majority of reported side effects of SGLT2 inhibitors, mainly an enhanced susceptibility to fungal and bacterial infections of the genital tract, do not minor the necessity and value of SGLT2 inhibitors, more serious effects appeared in several studies: a potential increased risk of foot amputations was reported and there might be clinical implications in special risk groups like patients with neuropathic ulcerations, both highly debated effects that need further investigation [12].