CCND1 expression correlated also with cell size and the senescence markers TP53, GLB1, SERPINE1 and ZMAT3. There was a gradual increase in cyclin D1, p16 and β-GAL in mature adipose cells comparing lean, obese and T2D individuals (Gustafson et al. 2022). Here, TP53 is linked to type 2 diabetes mellitus.