INS and type 2 diabetes mellitus: In earlier studies we have shown that the adipogenic potential of APC from human SAT has a high inter-individual variability and that markers for reduced adipogenesis, such as PPARγ and reduced lipid accumulation, reduced insulin sensitivity and increased inflammation correlate with hypertrophic obesity and genetic predisposition for T2D in FDR (Gustafson et al. 2013, 2015a, 2015b; Arner et al. 2011).