The European Medicines Agency (EMA) and Federal Drug Administration (FDA) approved the programmed death receptor 1 (PD-1) antibody pembrolizumab for the treatment of patients with early triple-negative breast cancer (TNBC) who are receiving neoadjuvant systemic therapy and for patients with advanced TNBC whose tumors express PD-L1 (graded as combined positive score, CPS ≥ 10) by means of the PD-L1 IHC 22C3 pharmDx test. This evidence concerns the gene CD274 and triple-negative breast carcinoma.