Similarly to GLUT1, GLUT3 mediates glucose uptake and its upregulation has also been reported in numerous types of cancer.16 In the study by Zhou, et al.21 (2008), GLUT3 gene expression in HNC was significantly higher when compared with non-malignant cases, and this was correlated with the occurrence of lymph node metastasis. This evidence concerns the gene SLC2A1 and metastatic malignant neoplasm in the lymph nodes.