Thus, this study aimed to evaluate the immunoexpression of the HIF targets GLUT1, GLUT3, HK2, PFKL, PKM2, phospho-PDH (pPDH), LDHA, MCT4, and CAIX in OPMD and OSCC lesions by immunohistochemistry, further characterizing their effect on the survival and clinicopathological parameters of patients. The gene discussed is CA9; the disease is oculopharyngeal muscular dystrophy.