LDHA and cancer: LDHA, by preferentially converting pyruvate to lactate, is frequently overexpressed in cancer and associated with aggressive features and poor prognosis,32 which was also observed in OSCC.33 In another study, LDHA increased expression clearly associated with the process of oral carcinogenesis.24 Our results are in line with these findings, since LDHA expression frequencies were similar in OPMD and OSCC sections.