Thus, this study aimed to evaluate the immunoexpression of the HIF targets GLUT1, GLUT3, HK2, PFKL, PKM2, phospho-PDH (pPDH), LDHA, MCT4, and CAIX in OPMD and OSCC lesions by immunohistochemistry, further characterizing their effect on the survival and clinicopathological parameters of patients. This evidence concerns the gene SLC2A1 and oculopharyngeal muscular dystrophy.