HK2 and neoplasm: For instance, the expression of GLUT1, CAIX, HK2, and LDHA was observed in OSCC cell lines under hypoxic conditions, similarly to what was found in clinical samples.24 Downregulation of PKM2 in OSCC cell lines decreased proliferation, invasion, and apoptosis induction.28 Genetic or pharmacological disruption of LDHA decreased proliferation, migration, invasion, and EMT of OSCC cell lines, and inhibited tumor growth in vivo.