Thus, this study aimed to evaluate the immunoexpression of the HIF targets GLUT1, GLUT3, HK2, PFKL, PKM2, phospho-PDH (pPDH), LDHA, MCT4, and CAIX in OPMD and OSCC lesions by immunohistochemistry, further characterizing their effect on the survival and clinicopathological parameters of patients. Here, LDHA is linked to oculopharyngeal muscular dystrophy.