OI is characterized by recurrent fractures, progressive skeletal deformities, and growth deficiency, blue or gray discoloration of the sclera and dentinogenesis imperfecta.70  Mutations in Serpinf1 have been reported in Chinese individuals with OI.46  Our findingSerpinf1 mainly high expressed during postnatal stages, indicated that Serpinf1 played an important role in the formation and mineralization of tooth hard tissues. Here, SERPINF1 is linked to osteogenesis imperfecta.