One study reported that, when patients were presented within 24 hours of symptoms appearing, the fasting time for the occurrence of hypoglycemia was <8 hours, the serum insulin concentration was ≥28 mU/mL and C‐peptide concentration was ≥4 ng/mL at the glycemic nadir, malignant insulinoma was more likely.21 This evidence concerns the gene INS and Hypoglycemia.