CD44 and malignant glioma: Although all subgroups can affect malignant cells through SPP1‐CD44‐mediated intercellular interactions, the role of M2‐like TAMs in SPP1‐CD44‐mediated intercellular interactions is most likely a key factor in promoting recurrence progression, given that only the proportion of M2‐like TAMs is significantly increased in the immune microenvironment of recurrent malignant gliomas.