Although all subgroups can affect malignant cells through SPP1‐CD44‐mediated intercellular interactions, the role of M2‐like TAMs in SPP1‐CD44‐mediated intercellular interactions is most likely a key factor in promoting recurrence progression, given that only the proportion of M2‐like TAMs is significantly increased in the immune microenvironment of recurrent malignant gliomas. This evidence concerns the gene SPP1 and malignant glioma.