Ovarian cancer cells cocultured with M2 macrophages showed the increased expression of the molecular toleration-like receptor (TLR4) in the tumour microenvironment (TME), which upregulated ALKBH5 by activating the NF-κB pathway, and eventually promoted ovarian carcinogenesis in the mock TME [82]. Here, ALKBH5 is linked to ovarian carcinoma.