Although Liu et al. [44] reported that miR-199a negatively regulated the growth of hepatocellular carcinoma cells by targeting CDC25A, miR-199a positively regulated hepatocyte proliferation by targeting TNF-α/TRADD/caspase 3 signaling, resulting in the acceleration of rat liver regeneration following 70%PH [45]. This evidence concerns the gene CASP3 and hepatocellular carcinoma.