Herein, we report the case of a patient with HAE who underwent bone marrow transplantation (BMT) for replication of blood cells in the patient and production of additional normal blood cells for acute myeloid leukemia (AML), which resulted in a gradual increase in C1-INH function over 40%, subsequently ameliorating an acute HAE attack. Here, SERPING1 is linked to acute myeloid leukemia.