ASS1 and idiopathic pulmonary fibrosis: In cell-based studies, we found downregulation of inositol-related signalosomes (e.g., EGFR and PKC signaling) when “extracellular” inositol was added to increase “intracellular” levels of inositol in IPF fibroblasts and/or ASS1-knockdown normal fibroblasts.