Hallmarks of renal fibrosis include overexpression of extracellular matrix (ECM) fibrils (collagen-I, fibronectin, etc.), up-regulation of epithelial to mesenchymal transition (EMT) markers (α-SMA, N-cadherin, Snail, etc.), and activation of TGFβ/Smad3 signaling pathway [4–6]. The gene discussed is TGFB1; the disease is renal fibrosis.