Significant increases in miRNAs (hsa-miR-206, hsa-miR-193b-5p) that target Tissue Inhibitors of Metalloproteases (TIMP)3 and TIMP4 activity that regulate amyloid precursor protein (APP) cleavage and are expressed at increased levels in AD brains, indicate a normalization of TIMP expression—further supporting the hypothesis that DDR1 inhibition promotes neurovascular health. Here, TIMP4 is linked to Alzheimer disease.