Research effort is currently dedicated to explore the relationship between pyroptosis-related genes and lung cancer, which concluded that overexpression of GSDMC has a predictive ability in the prognosis of lung adenocarcinoma [47],and PLCG1 as a critical mediator of the FGFR1 signaling, plays a vital in regulating neuroendocrine differentiation in small cell lung cancer [48]. The gene discussed is PLCG1; the disease is lung cancer.