Through OCLR algorithm, it can be seen that mRNAsi, EREG-MRNASI value has significant difference between the two clusters (p < 0.05) (Additional file 9), suggesting that FMR1, LRPPRC, RBMX, YTHDC2 and IGF2BP1 may affect CRC by regulating the pathway of basal cell carcinoma. This evidence concerns the gene FMR1 and colorectal carcinoma.