Through OCLR algorithm, it can be seen that mRNAsi, EREG-MRNASI value has significant difference between the two clusters (p < 0.05) (Additional file 9), suggesting that FMR1, LRPPRC, RBMX, YTHDC2 and IGF2BP1 may affect CRC by regulating the pathway of basal cell carcinoma. Here, IGF2BP1 is linked to colorectal carcinoma.