The activation of NLRP3 inflammasome could promote the proliferation and migration of lung adenocarcinoma A549 cells by mediating the release of IL-18 and IL-1β through the caspase-1 dependent pyroptosis pathway, while blocking IL-18 and IL-1β signaling could inhibit the progression of lung cancer [15]. The gene discussed is NLRP3; the disease is lung cancer.