The expression of GSDMD in PBMCs was related to lymph node involvement(P < 0.05); the expression of CASP1 was related to tumor diameter(P < 0.05); the expression of CASP4 was related to TNM staging and lymph node involvement(P < 0.05); the expression of CASP5 in NSCLC patients was related to tumor diameter(P < 0.05). The gene discussed is CASP5; the disease is neoplasm.