Excessive α-synuclein accumulation, dopaminergic neurodegeneration, mitochondrial and lysosomal dysfunction, impaired WNT-LMX1A autoregulation, defects in general neurogenesis, and increased neuronal misfiring were observed, validating the link between DNAJC6 and PD pathogenesis [117]. This evidence concerns the gene DNAJC6 and Parkinson disease.